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How Psychedelic or Hallucinogenic Drugs Work Although the salient features of psilocybin intoxication are blocked by the selective 5-HT2A antagonist ketanserin (Vollenweider et al., 1998), psilocin also has significant agonist activity at the 5-HT1A receptor (e.g., Blair et al., 2000). It is unknown to what extent intravenous administration of psilocybin might produce effects on neuronal function through activation of 5-HT1A receptors. Halberstadt and Geyer recently reviewed the Psychedelic topic of serotonergic hallucinogens as translational models relevant to schizophrenia. In their review, they note the many early groups that studied the effects of LSD, mescaline, and psilocybin, who concluded that these drugs produced mental states that resembled the earliest phases of schizophrenia. The four widely used animal behavioral models are startle habituation, PPI, HTRs in rodents, and deficits in temporal processing . There have been dozens of deaths reported as a direct result of B...